Genomics: Leprosy — a degenerative disease of the genome
نویسندگان
چکیده
Analysis of the genome of the leprosy bacillus uncovers evidence of extensive deletion and inactivation of genes. Secluded in a specialised niche, it has discarded much of its genetic heritage, though retaining just enough to be a major human pathogen.
منابع مشابه
Ancient Skeletal Evidence for Leprosy in India (2000 B.C.)
BACKGROUND Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects almost 250,000 people worldwide. The timing of first infection, geographic origin, and pattern of transmission of the disease are still under investigation. Comparative genomics research has suggested M. leprae evolved either in East Africa or South Asia during the Late Pleistocene before spreading to...
متن کاملژنومیکس انگل ها
Genes carry instructions to make protein that affect body's cells and their physical activity. They also play an important role in the occurrence of various characteristics in the body. Recently, scientists in the new field of science known as genomics have studied the genetic instructions. Genomics deals with the discovery of all the sequences in the entire genome of organisms and is used to s...
متن کاملI-44: Concurrent Whole-Genome Haplotyping and Copy-Number Profiling of Single Cells
Background Methods for haplotyping and DNA copynumber typing of single cells are paramount for studying genomic heterogeneity and enabling genetic diagnosis. Before analyzing the DNA of a single cell by microarray or next-generation sequencing, a whole-genome amplification (WGA) process is required, but it substantially distorts the frequency and composition of the cell’s alleles. As a conseque...
متن کاملO-38: Concurrent Whole-Genome Haplotyping and Copy-Number Profiling of Single Cells
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Leprosy is a rare but important infectious disease caused by mycobacterium leprae. Word health organization suggested a strategy to reduce the prevalence of the disease to less than one per 10000 people. It seems that the leprosy is now in its elimination stage because during a period of ten years only few new cases were found in Iran. We studied 157 new leprosy cases that were referred to and ...
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ورودعنوان ژورنال:
- Current Biology
دوره 11 شماره
صفحات -
تاریخ انتشار 2001